Cirrhosis is reported to be the 14th leading cause of death worldwide and the fourth leading cause of death in central Europe.
1 year mortality reported to range from 1% to 57% depending on occurrence of decompensating events.
About 2 million deaths worldwide annually are attributable to liver disease: 1 million due to cirrhosis and 1 million due to viral hepatitis and hepatocellular carcinoma.
Cirrhosis is the 11th most common cause of death, the third leading cause of death in people
aged 45–64 years, and together with liver cancer, accounts for 3.5% of all deaths worldwide.
10%-20% of patients with chronic liver disease progresses to cirrhosis
Definition
Cirrhosis of the liver is end-stage liver disease characterized by pathologic fibrosis and regenerative nodules with resultant liver dysfunction.
Most common causes of cirrhosis in the Western world are alcohol misuse, nonalcoholic fatty liver disease (or also known as metabolic associated liver disease), and viral hepatitis.
Increased alcohol consumption.
Hepatitis C most common viral cause of cirrhosis in US.
Hepatitis B most common viral cause of cirrhosis worldwide.
Classification
Child Pugh Classification for Severity of Liver Disease
5 to 6 points:
Child class A
7 to 9 points:
Child class B
10 to 15 points:
Child class C
Based on encephalopathy, ascites, bilirubin, albumin, PT time
Aetiology
Causes
Viral
Hepatitis B*
Hepatitis C*
Hepatitis D (usually superimposed on a hepatitis B infection)